Strategie anti invecchiamento: parte II

L’unico dato certo che emerge dagli studi attualmente in corso è che nella storia evolutiva della specie umana è inscritta l’alternanza tra periodi di normoalimentazione o sovralimentazione e digiuno, dovuta agli esiti della caccia o del raccolto stagionale o alle carestie che si sono susseguite nel corso della nostra evoluzione come specie e che l’obesità o in generale l’eccesso calorico sono praticamente la prima causa di morte odierna considerando che queste sono alla base di cancro, malattie cardiovascolari e diabete (fonte: Center for Disease Control).

Il recupero quindi di questa fisiologica alternanza può riattivare nell’organismo tutta una serie di complessi meccanismi riparativi che secondo le numerose teorie sull’invecchiamento possono rallentare i processi degenerativi, ridurre quelli infiammatori e allontare il rischio delle patologie sopra citate e, di conseguenza, aumentare l’aspettativa di vita.

Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women, M.C.Klempel et. al., Nutr J. 2012; 11: 98

R.E.Pattherson et al.,Intermittent Fasting and Human Metabolic Health, Journal of the American Academy of Nutrition and Dietetics, 2015

Azevedo, F.R., et al. Effects of intermittent fasting on metabolism in men. Rev Assoc Med Bras. 2013 Mar-Apr;59(2):167-73.

Fontana, L. et al. Dietary Restriction, Growth Factors and Aging: from yeast to humans. 329 (5976): 321-326 (2010)

Glass, D. et al. Recent advances in the biology and therapy of muscle wasting. Ann. N.Y. Acad. Sci. 1211 25-36 (2010)

Johnson, J.B. et al. Alternate Day Calorie Restriction Improves Clinical Findings and Reduces Markers of Oxidative Stress and Inflammation in Overweight Adults with Moderate Asthma. Free Radic Biol Med. 42 (5): 665:674 (2007)

Klempel et al. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal 2012, 11:98

Kroeger et al. Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations. Nutrition & Metabolism 2012, 9:98.

Longo, V. et al. Fasting: Molecular Mechanisms and Clinical Implications. Cell Metab. 19: 181:192 (2014).

Mercken, E.M. et al. Of Mice and Men: The Benefits of Caloric Restriction, Exercise, and Mimetics. Ageing Res Rev. 11(3): 390-398 (2012)

Mercken, E.M. et al. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 12(4): 646-651 (2013)

National Center for Health Statistics. Health, United States, 2011: With Special Feature on Socioeconomic Status and Health. Hyattsville, MD. 2012.

S Jay Olshansky, Dana P Goldman, Yuhui Zheng, John W Rowe. Aging in America in the Twenty-first Century: Demographic Forecasts from the MacArthur Foundation Research Network on an Aging Society Milbank Q. 2009 December; 87(4): 842–862.

Redman, L.M. et al. The effect of caloric restriction interventions on growth hormone secretion in non-obese men and women. Aging Cell. 9(1): 32-39 (2010)

Stipp, David. How Intermittent Fasting Might Help You Live a Longer and Healthier Life. Scientific American, Vol. 308/1, 2012.

Valerio, A. et al. Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perpective. 3 (5) 464-478 (2011)

Willcox, B.J. et al. Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications.  Curr Opin Clin Nutr Metab Care 17: 51-58 (2014)